Peptides for weight loss and digestion

Meme: when they ask how I lost the weight / me / my spirit peptides

From semaglutide to retatrutide: the GLP-1s and their cousins, plus the peptides that work on your gut.

Open them in the deck

BPC-157
Fifteen amino acids said to come from a gastric juice protein, sold to speed the repair of tendons, muscle and the gut lining.
The Fool · Not FDA approved
Tirzepatide
Two gut-hormone receptors, GIP and GLP-1, in one weekly shot: insulin rises with sugar, appetite drops. For diabetes and obesity.
The Chariot · FDA approved
Lutetium-177 Dotatate
Docks on the somatostatin receptors of hormone-making gut tumors, delivering lutetium-177, whose beta rays damage them up close.
Death · FDA approved
Semaglutide
GLP-1, a gut hormone, on a weekly contract: it slows your stomach and tells your brain 'we're full' before the second plate.
Temperance · FDA approved
Retatrutide
One molecule, three receptors: GLP-1 and GIP to curb appetite, glucagon to burn energy and pull fat out of the liver.
The Tower · In clinical trials
Gallium-68 Dotatate
Carries gallium-68 to somatostatin receptors on hormone-making gut tumors so they glow on a PET scan, flagging who gets lutetium.
Judgement · FDA approved
5-Amino-1MQ
Sold to burn fat, it blocks NNMT, an enzyme in fat cells, yet it is a small molecule lighter than caffeine, not a peptide.
Not FDA approved
Amycretin
One molecule hitting GLP-1 and amylin receptors, the fullness signals of gut and pancreas, for weight loss as a shot or a pill.
In clinical trials
AOD-9604
Amino acids 177 to 191 of growth hormone plus a tyrosine, sold to burn fat like the full hormone without its growth effects.
Not FDA approved
Apraglutide
GLP-2, the hormone that grows the gut lining, made to last a week, meant to help a short bowel absorb more and need less IV food.
In clinical trials
Brilacidin
Not a peptide, but it plays one: it mimics defensins, the immune system's germ-killing peptides. Aimed at radiation mouth sores.
Not FDA approved
Cagrilintide
A stabilized amylin with a fatty tail, so this pancreas fullness hormone lasts a week. Aimed at weight loss, solo or in CagriSema.
In clinical trials
CagriSema
Two molecules, one weekly shot: cagrilintide copies amylin and semaglutide copies GLP-1, two fullness signals, for weight loss.
In clinical trials
Dasiglucagon
Glucagon with 7 amino acids swapped to stay liquid in a ready pen: it makes the liver release glucose when blood sugar crashes.
FDA approved
Enlicitide
A daily pill that blocks PCSK9, the protein that destroys your liver's LDL receptors, so more bad cholesterol is cleared from blood.
FDA approved
Fragment 176-191
The last 16 amino acids of growth hormone, its C-terminal tail, sold alone as the fat-burning piece. The chorus without the song.
Not FDA approved
Glepaglutide
A twice-weekly copy of GLP-2, the hormone that grows the gut lining, meant to help a short bowel absorb more and cut IV feeding.
In clinical trials
Glucagon
Insulin's opposite, from the pancreas: in a severe sugar crash it makes the liver turn glycogen, its stored sugar, into glucose.
FDA approved
KPV
Lysine, proline, valine: the tail of alpha-MSH, the tanning hormone, sold to calm inflamed gut and skin without the tan.
Not FDA approved
Lanreotide
Copies somatostatin, the body's hormone brake, as a monthly gel that curbs excess growth hormone and slows some gut tumors.
FDA approved
Larazotide
Designed to close tight junctions, the seals between gut cells that gluten pries open in celiac disease, so the lining stays shut.
Not FDA approved
Linaclotide
Mimics an E. coli diarrhea toxin at guanylate cyclase-C, a gut-wall receptor, so the bowel secretes water. For constipation.
FDA approved
Liraglutide
A daily GLP-1 analog, the gut's fullness hormone, with a fatty tail that grips albumin so it lasts. For type 2 diabetes, obesity.
FDA approved
Mazdutide
Copies oxyntomodulin, a gut hormone that hits GLP-1 and glucagon receptors at once. Weekly, for obesity and type 2 diabetes.
In clinical trials
Octreotide
A longer-lived somatostatin, the hormone brake: it curbs excess growth hormone and the flushing and diarrhea of carcinoid tumors.
FDA approved
Pemvidutide
Built for MASH, inflamed fatty liver: a weekly shot that switches on GLP-1 and glucagon receptors so the liver burns its own fat.
In clinical trials
Petrelintide
A weekly analog of amylin, the pancreas hormone that signals fullness, meant for weight loss with less nausea than GLP-1s.
In clinical trials
Plecanatide
Copies uroguanylin, a gut hormone most active in the slightly acidic small intestine, where it pulls in water. For constipation.
FDA approved
PN-943
A pill meant to block alpha4beta7, the integrin white blood cells use to enter the gut wall. For ulcerative colitis.
Not FDA approved
Setmelanotide
Switches on MC4R, the brain's fullness receptor, in rare obesity where the signal upstream is broken. Side effect: darker skin.
FDA approved
Sincalide
CCK-8, the active tail of cholecystokinin, the hormone that empties the gallbladder. Injected during a scan to measure the squeeze.
FDA approved
Survodutide
Pairs GLP-1 with glucagon, its sugar-raising rival, so the liver burns fat while sugar stays calm. Enemies to lovers, weekly.
In clinical trials
Teduglutide
GLP-2 made enzyme-proof, taken daily: villi, the gut's absorbing folds, grow taller, so a short bowel needs less IV feeding.
FDA approved
Terlipressin
Releases lysine vasopressin, a vessel-tightening hormone, to clamp gut blood flow and divert it to kidneys failing in cirrhosis.
FDA approved
Tesamorelin
Copies GHRH so the pituitary releases its own growth hormone, shrinking visceral fat, the deep belly kind, in people with HIV.
FDA approved