Plecanatide

How it works

Copies uroguanylin, a gut hormone most active in the slightly acidic small intestine, where it pulls in water. For constipation.

What it's made of

16 amino acids: human uroguanylin with 1 change (a glutamic acid in place of an aspartic acid). Like uroguanylin, it is more active in the slightly acidic environment of the small intestine.

What it's for

Prescribed for

Chronic constipation and irritable bowel with constipation, only in adults.