Peptides for muscle and bone

Meme: when they ask for my sources / trust me (it was rats)

Bone builders, growth hormone boosters and the peptides gyms talk about, each with its real status.

Open them in the deck

Teriparatide
A daily pulse of parathyroid hormone's active end, spurring osteoblasts, the cells that lay down bone. For osteoporosis.
The Emperor · FDA approved
TB-500
Thymosin beta-4's actin-grabbing stretch; actin is the filament cells crawl with. Sold to speed muscle and tendon repair.
The World · Not FDA approved
Abaloparatide
Daily shots that stimulate osteoblasts, the cells that lay down bone, via the PTH1 receptor, building new bone in osteoporosis.
FDA approved
CJC-1295
The first 29 amino acids of GHRH, the brain's growth hormone trigger, armored against enzymes and sold to raise growth hormone.
Not FDA approved
Etelcalcetide
Mimics calcium at the parathyroid's calcium-sensing receptor, so the glands release less parathyroid hormone. Given after dialysis.
FDA approved
Follistatin-344
A 315-amino-acid protein that binds myostatin, the body's brake on muscle growth, sold in vials as a way to build mass.
Not FDA approved
GHRP-2
A ghrelin mimic that releases growth hormone from the pituitary, used to test how much it can still make. Also sold for muscle.
Not FDA approved
GHRP-6
Mimics ghrelin, the hunger hormone, at its pituitary receptor to release growth hormone. Made 15 years before ghrelin was found.
Not FDA approved
Hexarelin
A methylated GHRP-6 that mimics ghrelin to release growth hormone; somatostatin, the body's growth hormone brake, only blunts it.
Not FDA approved
IGF-1 DES
IGF-1, growth hormone's messenger, minus its first three amino acids so blood proteins trap it less. Sold for local muscle growth.
Not FDA approved
IGF-1 LR3
A longer IGF-1, growth hormone's messenger: 13 extra amino acids so blood proteins barely trap it. Sold as long-acting, for muscle.
Not FDA approved
Ipamorelin
Mimics ghrelin, the hunger hormone, at the pituitary to trigger one pulse of growth hormone. Sold as the one that spares cortisol.
Not FDA approved
MGF
Muscle makes this form of the growth factor IGF-1 when loaded or damaged. Vials sell only its tail, the E peptide, for repair.
Not FDA approved
MK-677
Not a peptide: an oral small molecule that mimics ghrelin, the hunger hormone, so growth hormone, IGF-1 and appetite all rise.
In clinical trials
Palopegteriparatide
Parathyroid hormone's active fragment on a PEG tether that frees it slowly all day. For hypoparathyroidism, when calcium runs low.
FDA approved
Parathyroid Hormone
The full 84-amino-acid parathyroid hormone, for failed glands: it raises blood calcium via kidney, gut and bone.
FDA approved
Salmon Calcitonin
Salmon calcitonin lowers blood calcium by calming osteoclasts, the cells that dissolve bone. For Paget's disease and high calcium.
FDA approved
Sermorelin
GHRH's first 29 amino acids, the brain's cue for the pituitary to release growth hormone. Sold as a 'natural' anti-aging boost.
Not FDA approved
Thymosin Beta-4
Traps loose actin, the building block of cells' crawling filaments, so it controls cell movement. Sold for repair; TB-500 is a piece.
In clinical trials
Vosoritide
Activates NPR-B in the growth plates, mimicking CNP, a natural bone-growth peptide, so children with achondroplasia grow faster.
FDA approved
Zilucoplan
In myasthenia gravis, this ring peptide blocks complement C5, an immune attack protein, shielding the nerve-muscle junction.
FDA approved